Review



gna modification  (Alnylam Inc)

 
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 86
      Buy from Supplier

    Structured Review

    Alnylam Inc gna modification
    <t>siRNA</t> sequence and chemical structures of mononucleotides (A) Schematic of the parent siRNA duplex targeting human PCSK9. This siRNA was previously characterized. (B) Structures of 2′-OMe, 2′-F, ( S <t>)-GNA,</t> natural phosphate, and phosphorothioate linkages. (C) Structures of 2′-modified mononucleotides used in this study.
    Gna Modification, supplied by Alnylam Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/gna+modification/pmc12870468-186-8-4?v=Alnylam+Inc
    Average 86 stars, based on 1 article reviews
    gna modification - by Bioz Stars, 2026-08
    86/100 stars

    Images

    1) Product Images from "2′-Ribose-modified nucleotides: A strategy for reducing off-target effects of oligonucleotide drugs"

    Article Title: 2′-Ribose-modified nucleotides: A strategy for reducing off-target effects of oligonucleotide drugs

    Journal: Molecular Therapy. Nucleic Acids

    doi: 10.1016/j.omtn.2026.102835

    siRNA sequence and chemical structures of mononucleotides (A) Schematic of the parent siRNA duplex targeting human PCSK9. This siRNA was previously characterized. (B) Structures of 2′-OMe, 2′-F, ( S )-GNA, natural phosphate, and phosphorothioate linkages. (C) Structures of 2′-modified mononucleotides used in this study.
    Figure Legend Snippet: siRNA sequence and chemical structures of mononucleotides (A) Schematic of the parent siRNA duplex targeting human PCSK9. This siRNA was previously characterized. (B) Structures of 2′-OMe, 2′-F, ( S )-GNA, natural phosphate, and phosphorothioate linkages. (C) Structures of 2′-modified mononucleotides used in this study.

    Techniques Used: Sequencing, Modification



    Similar Products

    gna modification  (Alnylam Inc)
    86
    Alnylam Inc gna modification
    <t>siRNA</t> sequence and chemical structures of mononucleotides (A) Schematic of the parent siRNA duplex targeting human PCSK9. This siRNA was previously characterized. (B) Structures of 2′-OMe, 2′-F, ( S <t>)-GNA,</t> natural phosphate, and phosphorothioate linkages. (C) Structures of 2′-modified mononucleotides used in this study.
    Gna Modification, supplied by Alnylam Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/gna+modification/pmc12870468-186-8-4?v=Alnylam+Inc
    Average 86 stars, based on 1 article reviews
    gna modification - by Bioz Stars, 2026-08
    86/100 stars
    		  Buy from Supplier
    gna modification pattern  (Alnylam Inc)
    90
    Alnylam Inc gna modification pattern
    <t>siRNA</t> sequence and chemical structures of mononucleotides (A) Schematic of the parent siRNA duplex targeting human PCSK9. This siRNA was previously characterized. (B) Structures of 2′-OMe, 2′-F, ( S <t>)-GNA,</t> natural phosphate, and phosphorothioate linkages. (C) Structures of 2′-modified mononucleotides used in this study.
    Gna Modification Pattern, supplied by Alnylam Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/gna+modification/pmc12083919-212-1-6?v=Alnylam+Inc
    Average 90 stars, based on 1 article reviews
    gna modification pattern - by Bioz Stars, 2026-08
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    siRNA sequence and chemical structures of mononucleotides (A) Schematic of the parent siRNA duplex targeting human PCSK9. This siRNA was previously characterized. (B) Structures of 2′-OMe, 2′-F, ( S )-GNA, natural phosphate, and phosphorothioate linkages. (C) Structures of 2′-modified mononucleotides used in this study.

    Journal: Molecular Therapy. Nucleic Acids

    Article Title: 2′-Ribose-modified nucleotides: A strategy for reducing off-target effects of oligonucleotide drugs

    doi: 10.1016/j.omtn.2026.102835

    Figure Lengend Snippet: siRNA sequence and chemical structures of mononucleotides (A) Schematic of the parent siRNA duplex targeting human PCSK9. This siRNA was previously characterized. (B) Structures of 2′-OMe, 2′-F, ( S )-GNA, natural phosphate, and phosphorothioate linkages. (C) Structures of 2′-modified mononucleotides used in this study.

    Article Snippet: To address this issue, Alnylam Pharmaceuticals has employed GNA modification at position 7 of the siRNA antisense strand to disrupt the seed region, thereby significantly reducing off-target effects and alleviating hepatocellular toxicity.

    Techniques: Sequencing, Modification